VIRTUAL SCREENING OF NATURAL ALPHA-GLUCOSIDASE INHIBITOR FROM ALPINIA GALANGA BIOACTIVE COMPOUNDS AS ANTI-DIABETIC CANDIDATE

Glucose toxicity become serious risk factor of type 2 diabetes mellitus. Multiple complication can be caused the abnormal condition glucose level in blood. Thus, managing plasma is one strategy to minimize negative effects In this present study, we aimed virtually evaluate bioactive compounds from Alpinia galanga as inhibitor agent against alpha-glucosidase, which was known carbohydrate catabolic enzyme. The 2D structure ligands were retrieved PubChem database (pubchem.ncbi.nlm.nih.gov/) and evaluated based on Lipinski rule five for ensured druglike-ness standard, while sequence 3D target protein, UniProt (https://www.uniprot.org/) modelled through SWISS-MODEL (swissmodel.expasy.org/). All used study then underwent optimization prior molecular docking analyzing procedures. According our prediction results, found that galangin 1's-1'-acetoxychavicol acetate A. have significant potency agents alpha-glucosidase due its binding affinity scores other physicochemical properties compared anti-diabetic drug, mignitol. finding, recent starting point expand these compounds, especially inhibiting novel reduce poor prognosis